Jean-Louis BESSEREAU — Professor, UCBL
Allan ALCOLEI — PhD Student
Mélissa CIZERON — Post-doc
Manuela D’ALESSANDRO — Researcher, INSERM
Franklin FLORIN — PhD Student
Evan GOUY — Researcher, HCL
Laure GRANGER — Research Assistant, CNRS
Maëlle JOSPIN — Assistant Professor, UCBL
Driss LAABID — Research Assistant, UCBL
Morgane MIALON — PhD Student
Laurent MOLIN — Research Assistant, CNRS
Minh Dao NGUYEN — PhD Student
Bérangère PINAN-LUCARRÉ — Researcher, INSERM
Charline ROY — PhD Student
Florence SOLARI — Researcher, INSERM
Synapses are sophisticated nanomachines that support transfer and processing of information between excitable cells.
Since most neurons receive thousands of synaptic inputs, the neuronal membrane is a mosaic of specialized microdomains where neurotransmitter receptors cluster in register with the corresponding presynaptic neurotransmitter release sites. Our lab is interested in identifying the cellular and molecular mechanisms involved in the organization and maintenance of the synapse with a specific focus on the control of neurotransmitter receptor expression and localization.
Our strategy is based on the combination of genetics, imaging, electrophysiology and biochemistry in the nematode Caenorhabditis elegans (for more information on C. elegans see “an overview of the model organism C. elegans“). Using the neuromuscular synapse as a model synapse, we identified several new genes involved in the clustering of acetylcholine and GABAA receptors through previously undescribed mechanisms, including a novel anterograde synaptic organizer that assembles extracellular scaffolds in the synaptic cleft. We are currently analyzing the organization, dynamics and maintenance of these synaptic scaffolds as well as the genes involved in the biosynthesis and trafficking of the receptors.
Our results should contribute to a better understanding of the normal and pathological synapse. Specifically, synaptic defects have been involved over the last years in the pathogenesis of a growing number of neuropsychiatric diseases, leading to the concept of “synaptopathies”. However, a number of genes linked to neuropsychiatric diseases have no assigned function, and it is likely that the mutational landscape of these diseases will be complexified by the wealth of data generated with next generation sequencing techniques. Simple organisms should help!
Join the teamWe have currently no funded position but we are always looking for talented and highly motivated students or postdocs.
- Jean-Louis BESSEREAU — Professor, UCBL
- Allan ALCOLEI — PhD Student
- Mélissa CIZERON — Post-doc
- Manuela D’ALESSANDRO — Researcher, INSERM
- Franklin FLORIN — PhD Student
- Evan GOUY — Researcher, HCL
- Laure GRANGER — Research Assistant, CNRS
- Maëlle JOSPIN — Assistant Professor, UCBL, HDR
- Driss LAABID — Research Assistant, UCBL
- Morgane MIALON — PhD Student
- Laurent MOLIN — Research Assistant, CNRS
- Minh Dao NGUYEN — PhD Student
- Bérangère PINAN-LUCARRÉ — CV — Researcher, INSERM, HDR
- Charline ROY — PhD Student
- Florence SOLARI — Researcher, INSERM
- Specific heparan sulfate modifications stabilize the synaptic organizer MADD-4/Punctin at Caenorhabditis elegans neuromuscular junctions.
Cizeron M, Granger L, Bülow HE, Bessereau JL.
Genetics (2021) — Show abstract
- The HSPG Syndecan is a core organizer of cholinergic synapses.
Zhou X, Vachon C, Cizeron M, Romatif O, Bülow HE, Jospin M, Bessereau JL.
J Cell Biol (2021) — Show abstract
- The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors.
Zhou X, Gueydan M, Jospin M, Ji T, Valfort A, Pinan-Lucarré B, Bessereau JL.
Nature Communication (2020) — Show abstract
- CRELD1 is an evolutionarily-conserved maturational enhancer of ionotropic acetylcholine receptors.
D’Alessandro M, Richard M, Stigloher C, Gache V, Boulin T, Richmond JE, Bessereau JL.
Elife (2018) — Show abstract
- UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans.
Mergoud Dit Lamarche A, Molin L, Pierson L, Mariol MC, Bessereau JL, Gieseler K, Solari F.
Aging Cell (2018) — Show abstract
- Preventing Illegitimate Extrasynaptic Acetylcholine Receptor Clustering Requires the RSU-1 Protein.
Pierron M, Pinan-Lucarré B, Bessereau JL.
Journal of Neuroscience (2016) — Show abstract
- C. elegans Punctin Clusters GABA(A) Receptors via Neuroligin Binding and UNC-40/DCC Recruitment.
Tu H, Pinan-Lucarré B, Ji T, Jospin M, Bessereau JL.
Neuron (2016) — Show abstract
- Transcriptional coordination of synaptogenesis and neurotransmitter signaling.
Kratsios P, Pinan-Lucarré B, Kerk SY, Weinreb A, Bessereau JL, Hobert O.
Current Biology (2015) — Show abstract
- C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains.
Pinan-Lucarré B, Tu H, Pierron M, Cruceyra PI, Zhan H, Stigloher C, Richmond JE, Bessereau JL.
Nature (2014) — Show abstract
- Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex.
Richard M, Boulin T, Robert VJ, Richmond JE, Bessereau JL.
PNAS (2013) — Show abstract
- Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit.
Boulin T, Rapti G, Briseño-Roa L, Stigloher C, Richmond JE, Paoletti P, Bessereau JL.
Nature Neuroscience (2012) — Show abstract
- A secreted complement-control-related protein ensures acetylcholine receptor clustering.
Gendrel M, Rapti G, Richmond JE, Bessereau JL.
Nature (2009) — Show abstract
- Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor.
Boulin T, Gielen M, Richmond JE, Williams DC, Paoletti P, Bessereau JL.
PNAS (2008) — Show abstract
- A transmembrane protein required for acetylcholine receptor clustering in Caenorhabditis elegans.
Gally C, Eimer S, Richmond JE, Bessereau JL.
Nature (2004) — Show abstract
- Agence Nationale de la Recherche
- Labex CORTEX website
- 2016-2021 AFM Téléthon — Alliance MyoNeurALP
- 2015-2021 European Research Council